Warm Autoimmune Hemolytic Anemia (wAIHA)

Blood Disorders & Cancer
Warm Autoimmune Hemolytic Anemia (wAIHA)

Overview

Warm autoimmune hemolytic anemia (wAIHA) is an autoimmune condition in which red blood cells are destroyed prematurely, resulting in a decrease in the body's red blood cell count. wAIHA is referred to as warm because the antibodies that attach to red blood cells to cause their destruction are most active at normal body temperature.

At A Glance
Blood Disorders & Cancer condition Autoimmune condition

Common Signs And Symptoms

  • Fatigue And Dizziness
  • Paleness Of Skin
  • Shortness Of Breath And Difficulty Breathing
  • Mild Splenomegaly Enlargement Inflammation Of The Spleen
  • Jaundice Yellowing Of Skin And Eyes
  • Heart Palpitations

People with warm autoimmune hemolytic anemia may experience a variety of symptoms including:

Diagnosis Journey

The following tests can be used to confirm a diagnosis of wAIHA:

Clinical History:Doctors will perform a comprehensive clinical evaluation and review the patient's medical history.Blood Tests:Blood tests are performed to confirm anemia and hemolysis (destruction of red blood cells).Coombs Test:A Coombs test evaluates the presence of antibodies that are bound to red blood cells.

Treatment Options

Explore the treatment options available for wAIHA:

  • 01CorticosteroidsPrednisone is often used as the first line of treatment for wAIHA to suppress the immune system and decrease the destruction of red blood cells.
  • 02RituximabRituximab is a monoclonal antibody targeting certain white blood cells that produce antibodies that cause red blood cells to be destroyed prematurely.
  • 03SplenectomyThe spleen is the primary site of hemolysis (red blood cell destruction) in wAIHA. Sometimes, spleen removal may be necessary in very severe cases of wAIHA that have not responded to treatment.
  • 04TransfusionsIn other severe cases, red blood cell transfusions could be required to maintain proper red blood cell values.

Ongoing Research

wAIHA is a rare disease that requires more effective treatment options. To find these new treatments for wAIHA, further research is necessary.

Current Research Studies

There are approximately 9 wAIHA research studies that are actively recruiting participants. Visit ClinicalTrials.gov to find wAIHA research studies near you.

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