Eosinophilic Esophagitis (EoE)
Overview
Eosinophilic esophagitis (EoE) is an allergic inflammatory disease which occurs when large numbers of white blood cells, known as eosinophils, are found in the esophagus.
Common Signs And Symptoms
- Abdominal And Chest Pain
- Difficulty Swallowing Dysphagia
- Food Stuck In The Throat Impaction
- Persistent Heartburn
- Reflux
- Vomiting And Nausea
People with eosinophilic esophagitis may experience a variety of symptoms including:
Diagnosis Journey
For individuals showing signs and symptoms that are consistent with eosinophilic esophagitis, doctors may conduct the following tests to confirm a diagnosis:
Treatment Options
Although there is currently no known cure for EoE, treatment and medications can alleviate signs and symptoms.
Medication
- 01CorticosteroidsCorticosteroids help suppress inflammatory genes to reduce inflammation.
- 02Proton Pump InhibitorsProton pump inhibitors may help reduce acid production in the stomach.
- 03Monoclonal antibodiescan help block proteins that cause inflammation. Dupilumab (Dupixent) is a monoclonal antibody that was recently approved by the FDA for treatment of EoE in adults and children 12 years or older.
Diet Modifications
Some foods may make symptoms worse for people with EoE. It can be helpful to keep track of foods that are easier and more difficult to eat. Examples of diet modifications to help reduce the symptoms of EoE include:
Food test-directed elimination diets: The blood is tested for food sensitivities and these foods are removed from the diet.
- 04SFED(Six-food elimination diet)Diet to avoid the top 6 food allergens (wheat, milk, eggs, nuts, soy, fish/shellfish).
Ongoing Research
EoE is a disease that requires more effective treatment options. In order to find these new treatments, further research is necessary.
Current Research Studies
There are over 30 eosinophilic esophagitis research studies that are actively recruiting participants. Visit ClinicalTrials.gov to find EoE research studies near you.
Research & Resources
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