Autoimmune hepatitis (AIH) is a rare autoimmune disease where the immune system attacks the liver, causing inflammation that can lead to scarring or liver damage over time.
Fatigue
Abdominal pain
Joint pain
Jaundice (yellowing of skin and eyes)
Loss of appetite
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Dark (tea colored) urine
Itching
There are two main types of AIH, based on the antibodies found in blood tests:
Diagnosing AIH often requires multiple steps, since its symptoms can look like other liver diseases. The process may include:
Because AIH is rare, diagnosis may take time and often involves a specialist such as a hepatologist.
Treatment usually involves medicines that suppress the immune system to control vessel inflammation and prevent relapses. Common therapies include:
With treatment, many patients achieve remission, though relapses can occur. Lifelong monitoring is usually needed.
If autoimmune hepatitis is not diagnosed or treated early, ongoing inflammation can lead to serious liver damage over time. Potential complications include fibrosis (scarring of the liver), cirrhosis, liver failure, and an increased risk of liver cancer. Some people may also develop related autoimmune conditions affecting other organs, such as the thyroid or joints.
Researchers are working to better understand the causes of AIH and to develop new treatment options with fewer side effects. Clinical studies are exploring:
You can explore ongoing studies for Autoimmune Hepatitis on ClinicalTrials.gov or search available opportunities here on PatientWing.
Find an online community of fellow patients, caregivers, and advocates below as
as well as some other general resources!
