Lupus

Lupus is a chronic autoimmune disease that commonly causes inflammation in various parts of the body, including the joints, skin, and major organs such as the brain, kidneys, heart, and lungs.

Lupus

Lupus is a chronic autoimmune disease that commonly causes inflammation in the joints, skin, and major body organs, including the brain, heart, and lungs.  

Types of Lupus

  • Systemic lupus erythematosus (SLE): When people refer to lupus, they are typically referring to this type. SLE may affect the skin, joints, brain, kidneys, and other organs. Lupus nephritis (LN) is a severe complication of SLE that occurs when the kidneys are affected. SLE makes up 70% of patients with lupus, making it the most common form. 
  • Cutaneous lupus erythematosus: This type of lupus impacts the skin, resulting in rashes and lesions.
  • Drug-induced lupus: This form of lupus is triggered by certain prescription medications. The symptoms of drug-induced lupus are similar to those of systemic lupus erythematosus (SLE) and typically resolve within six months of discontinuing the medication that triggered the condition.
  • Neonatal lupus: This is a rare type of lupus that affects infants of women with lupus. Infants with neonatal lupus typically outgrow symptoms after around six months of age.

Complications of Lupus

Lupus may cause the development of complications and health risks in the following parts of the body: 
  • Kidneys: Lupus nephritis (kidney inflammation) is one of the most common complications of lupus that can result in kidney damage and failure.
  • Heart: Lupus may increase the risk of cardiovascular disease and heart attacks.
  • Blood: Complications involving blood in lupus include anemia (low red blood cell count), leukopenia (low white blood cell count), and thrombocytopenia (low platelet count). There is also an increased risk of blood clotting.
  • Lungs: Complications involving the lungs includes inflammation of the chest cavity lining, bleeding in the lungs, and pneumonia.
  • Brain and Central Nervous System: Complications involving the brain and central nervous system in lupus may include behavior changes, strokes, seizures, vision problems, and memory problems.


Symptoms

People with lupus may experience a variety of signs and symptoms. The most common symptoms include:
“Butterfly” facial rash covering cheeks and nose and other rashes on the body  
Fatigue
Pain, stiffness, and swelling of joints
Sensitivity to sunlight
Fever
Fingers and toes turning white or blue when stressed or exposed to the cold
Shortness of breath and chest pain
Headaches and confusion
Hair loss

Diagnosis Journey

Learn more about how people who are experiencing signs and symptoms of lupus can be diagnosed.  
If you notice that you are experiencing symptoms of lupus including unexplained rash, persistent fever, aches and pains, or extreme fatigue, consult with your healthcare provider. Your doctor will examine you, discuss your symptoms, ask about your family history, and potentially do additional tests if lupus is suspected.  
Process for diagnosis
There is no single test to diagnose lupus. However, doctors can diagnose individuals by using a combination of the following methods:
  • Medical history: Doctors may review medical history and documentation of symptoms.
  • Family history: Doctors may discuss if there is a family history of lupus or other autoimmune diseases.
  • Complete physical exam: Doctors will look for rashes or other signs and symptoms of lupus.
  • Urine tests: Doctors conduct urine tests to evaluate kidneys and detect any potential issues.
  • Blood tests: These tests can detect signs of inflammation and see how the immune system is functioning. Examples of blood tests include a complete blood count, antinuclear antibody (ANA) test, blood clotting time tests, and complement tests.
  • Biopsies: Doctors may perform a biopsy to detect inflammation, damage, and other signs of an autoimmune disease.

If you feel that you are not receiving adequate treatment, don't be afraid to explore other physicians and specialists in order to get the care you need.

Specialists

John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link

Registered doctors

John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link
John Smith, MD

Gastroenterologist • Nashville, TN

Link

Ongoing Research and Treatment Options

Lupus is a disease that requires more effective treatment options. To find these new treatments for lupus, further research is necessary.  

Current Research Studies

There are over 250 clinical trials actively recruiting participants with lupus. Search this site to find epilepsy research studies near you.

Featured Study

SPOTLIGHT Study

If you have lupus nephritis, explore the SPOTLIGHT study to learn about a potential treatment which aims to reduce protein excretion in the urine and reduce kidney function loss, both of which may lead to the need for dialysis or kidney transplantation.
Learn More

Treatment Options:

There is no cure for lupus, so treatment is focused on mitigating and improving symptoms. Commonly, patients see a rheumatologist for their lupus-related care. Treatments aim to:
  • Limit flares
  • Treat symptoms
  • Reduce organ damage and inflammation  

Medications

Common medications to help treat symptoms of lupus include:
  • Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs can help reduce pain, swelling and inflammation.
  • Corticosteroids: Corticosteroids may help reduce inflammation, swelling, and pain.  
  • Immunosuppressants: Immunosuppressants are used to suppress the immune system and reduce inflammation. They are typically reserved for severe cases of lupus or when other treatments have not been effective.
  • Antimalarial drugs: Antimalarial drugs can help reduce pain, inflammation, rashes, and flares.
  • Biologics: Biologics may alleviate symptoms by helping the immune system work properly.  
  • Additional medications might be necessary to address complications associated with lupus, such as high blood pressure, elevated cholesterol levels, osteoporosis, blood clots, etc.

Kidney Transplant

Individuals with lupus nephritis, a condition where lupus affects the kidneys, may require a kidney transplant if inflammation is severe and medications are unable to prevent significant kidney damage.  

Resources

Find an online community of fellow lupus patients, caregivers, and advocates below as well as some other general resources!

Lupus Warriors
A support group for those diagnosed with lupus to find emotional support, information, answers to questions, and relationships with others.
Lupus Support Group  
A group where people with lupus can ask questions, obtain information, and give and receive support.
Lupus Awareness
A support group for those living with lupus to share experiences and gain support.  
Reddit Group: r/Lupus
A Reddit community for those living with lupus to connect with others and share experiences.  
Lupus Research Alliance
The Lupus Research Alliance is an organization dedicated to funding research and ultimately finding a cure for lupus.
Lupus Foundation of America
The Lupus Foundation of America is an organization whose mission is to improve the quality of life for all people affected by lupus through research, support, education, and advocacy programs.  
World Lupus Federation
The World Lupus Federation supports the mission of other lupus groups worldwide to help improve the lives of those affected by lupus.
Looms for Lupus
Looms for Lupus is a non-profit organization that provides mental health awareness, advocacy, and support to those affected by lupus.
Lupus: The Expert Series
Tune in to this educational podcast featuring lupus experts discussing important topics and sharing valuable insights.  
Lupus Academy  
Listen to this podcast featuring experts discussing challenging cases and exciting developments for lupus.
More Than Lupus | Blog
Check out the blogs on the More Than Lupus website to learn more about lupus and gain insights from individuals sharing their personal experiences with the condition.

National Resource Center on Lupus  
The Lupus Foundation of America provides a mental health resource that features various articles regarding mental health and lupus.  

LupusLine
LupusLine is a national telephone peer-support program that offers one-on-one emotional support to people with lupus.

Surprising Mechanism of Lupus Kidney Damage Identified

Read this article to learn about a research team that identified key cells responsible for severe kidney damage in lupus.

Hydroxychloroquine Monitoring Associated with Lower Hospital Visits in People with Lupus

Visit this article to learn about a recent study suggesting that regularly checking blood levels of hydroxychloroquine may reduce emergency room visits and hospitalizations for people with lupus.

Events | Lupus Foundation of America

Find events hosted by the Lupus Foundation of America at this website.

Walk to End Lupus Now

Walk to End Lupus Now is a fundraising and awareness event for people affected by lupus and their families. Visit the website to register for a walk in your state.

FAQs

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